Theoretical and manipulative abduction conjectures and manipulations : the extra-theoretical dimension of scientific discovery. -- Non-explanatory and instrumental abduction : plausibility, implausibility, ignorance preservation. -- Semiotic brains and artificial minds : how brains make up material cognitive systems. -- Neuromultimodal abduction : pre-wired brains, embidiment, neurospaces. -- Animal abduction : from mindless organisms to srtifactual mediators. -- Abduction, affordances, and cognitive niches : sharing representations and creating chances through cognitive niche construction. -- Abduction in human and logical agents : hasty (...) generalizers, hybrid abducers, fallacies. -- Morphodynamical abduction : causation of hypotheses by attractors dynamics. (shrink)

Lorenzo Valla (1407–1457) ranks among the greatest scholars and thinkers of the Renaissance. He secured lasting fame for his brilliant critical skills, most famously in his exposure of the “Donation of Constantine,” the forged document upon which the papacy based claims to political power. Lesser known in the English-speaking world is Valla's work in the philosophy of language—the basis of his reputation as the greatest philosopher of the humanist movement. Dialectical Disputations, translated here for the first time into any (...) modern language, is his principal contribution to the philosophy of language and logic. With this savage attack on the scholastic tradition of Aristotelian logic, Valla aimed to supersede it with a new logic based on the actual historical usage of classical Latin and on a commonsense approach to semantics and argument. Valla provides a logic that could be used by lawyers, preachers, statesmen, and others who needed to succeed in public debate—one that was stylistically correct and rhetorically elegant, and thus could dispense with the technical language of the scholastics, a “tribe of Peripatetics, perverters of natural meanings.” Valla's reformed dialectic became a milestone in the development of humanist logic and contains startling anticipations of modern theories of semantics and language. Volume 1 contains Book I, in which Valla refutes Aristotle's logical works on the categories, transcendentals, and predicables, with excursions into natural and moral philosophy and theology. (shrink)

At the centenary of the creation of Diary of a Newlywed Poet, this paper elaborates on its metaphysical discovery. Building on the relevant concepts of the poet's aesthetics, it discovers the search for meaning in the poems in the light of sensitive enrichment, the understanding of reality and the stimulation of the receiver's conscience. The study was performed in the triple sense of cultivation, term under which the poet held a theory of human development, as cultivation of sensitivity, intelligence and (...) conscience. (shrink)

In recent years, a new dispute has risen to prominence: the dispute between realists and anti-realists about causal powers. Albeit sometimes overlooked, the meta-ontological features of this “question of realism for powers” are quite peculiar. For friends and foes of causal powers have characterized their contrasting views in a variety of different ways; as existence claims, as semantic or truth-making claims, as fundamentality claims, as claims about the nature of certain properties. Not only does this multiplicity of interpretations make it (...) unclear what the genuine bone of contention is, if there is one; some of them appear to be mutually exclusive. Some light can be shed on this apparent yet widespread confusion by distinguishing three degrees of ontological involvement in dispositional truths; viz., three ways, of increasing robustness, to read ontological commitments from dispositional truths. Relatedly, by exploring the literature, and focusing on some selected examples of power realism and anti-realism, we can observe that power realists vastly disagree over the intrinsic nature ad make-up of dispositional properties. Such examples furthermore invite the thought that the question of realism for powers is best understood not as the debate around the existence of properties with a distinctive identity, but rather as a debate about metaphysical hierarchy. Finally, some anti-realists positions are indistinguishable from realist ones, using merely intensional resources: power realism is best appreciated by going hyperintensional. (shrink)

This paper attempts a reconstruction of reason’s contribution to empirical truth in connection with Kant’s definition of truth as the agreement of cognition with its object. I argue that Kant’s treatment of truth in the Transcendental Analytic gets completed in the Appendix to the Transcendental Dialectic with an often neglected but compelling argument (what I shall call the Variety Argument). This argument postulates such a variety in the appearances as to undermine any attempt at formulating empirical truths. Crucially, I argue (...) that this variety does not depict an extreme-case scenario, but our own epistemic situation without reason. Reason completes Kant’s theory of truth by allowing the understanding (i.) to form empirical concepts and (ii.) approximate to empirical truth. (shrink)

Philosophers have debated at length the epistemological status of scientific thought experiments. I contend that the literature on this topic still lacks a common conceptual framework, a lacuna that produces radical disagreement among the participants in this debate. To remedy this problem, I suggest focusing on the distinction between the internal and the external validity of an experiment, which is also crucial for thought experiments. I then develop an account of both kinds of validity in the context of thought experiments. (...) I show that we can naturally conceptualise internal validity in terms of games of make-believe. Then, I argue that external validity is best defined as accurate representation of a target system. Finally, I turn back to the current debate on thought experiments and show that my diarchic account provides a general framework that can be shared by the competing philosophical views, as well as a fruitful guide for their reconciliation. (shrink)

We present an elementary system of axioms for the geometry of Minkowski spacetime. It strikes a balance between a simple and streamlined set of axioms and the attempt to give a direct formalization in first-order logic of the standard account of Minkowski spacetime in [Maudlin 2012] and [Malament, unpublished]. It is intended for future use in the formalization of physical theories in Minkowski spacetime. The choice of primitives is in the spirit of [Tarski 1959]: a predicate of betwenness and a (...) four place predicate to compare the square of the relativistic intervals. Minkowski spacetime is described as a four dimensional ‘vector space’ that can be decomposed everywhere into a spacelike hyperplane - which obeys the Euclidean axioms in [Tarski and Givant, 1999] - and an orthogonal timelike line. The length of other ‘vectors’ are calculated according to Pythagora’s theorem. We conclude with a Representation Theorem relating models of our system that satisfy second order continuity to the mathematical structure called ‘Minkowski spacetime’ in physics textbooks. (shrink)

OBJECTIVES: To review the characteristics and performance of research ethics committees in Spain in the evaluation of multicentre clinical trial drug protocols. DESIGN: A prospective study of 100 applications. SETTING: Forty-one committees reviewing clinical trial protocols, involving 50 hospitals in 25 cities. MAIN MEASURES: Protocol-related features, characteristics of research ethics committees and evaluation dynamics. RESULTS: The 100 applications involved 15 protocols (of which 12 were multinational) with 12 drugs. Committees met monthly (except one). They had a mean number of 12 (...) members, requested a mean of six complete dossiers and nine additional copies of the protocol with a mean deadline of 14 days before the meeting. All applications were approved except three (two of the three were open-label long-term safety trials rejected by the same committee), which were approved by the other committees involved. The mean time from submission to approval was 64 days. The mean time from submission to arrival of the approval document at our offices was 85 days. Twenty-five committees raised queries for 38 of the 97 finally approved applications. Impact of evaluation fee, number of members, queries raised and experience of committees on timings were not statistically significant. CONCLUSION: Obtaining ethical approval is time-consuming. There is much diversity in the research ethics committees' performance. A remarkable delay (> 20 days) exists between the decision and the arrival of the written approval, suggesting administrative or organisational problems. (shrink)

In this paper, we embark on the complicated discussion about the nature of vice in Virtue Ethics through a twofold approach: first, by taking seriously the claim that virtues (and certain flavours of vices) are genuinely dispositional features possessed by agents, and secondly, by employing a pluralistic attitude borrowed from Battaly’s pluralism (2008). Through these lenses, we identify three varieties of viciousness: incontinence, indifference, and malevolence. The upshot is that the notion of vice is not as categorically homogeneous as that (...) of virtue: some states of viciousness consist in interference of present virtuous dispositions, or mimicking of absent vicious ones, whereas others can be considered genuine dispositions themselves. Furthermore, this set-up can provide an interesting, albeit highly idealized story as to how, through the interference in one’s environment, one gets acquainted with vice in various degrees. Finally, this approach can be illuminating vis-à-vis Virtue Ethics in general; e.g. we can employ it to discuss more productively Johnston’s (2003) objection to Hursthouse’s (1999) account of moral conduct. Finally, this approach can be illuminating vis-a-vis Virtue Ethics in general; e.g. we can employ it to discuss more productively Johnston’s (2003) objection to Hursthouse’s (1999) account of moral conduct. (shrink)

This article aims to justify the positive role in the empirical investigation of nature that Kant attributes to the idea of God in the Critique of Pure Reason. In particular, I propose to read the Transcendental Ideal section and the Appendix to the Transcendental Dialectic together to see whether they can reciprocally illuminate each other. I argue that it is only by looking at the transcendental deduction of the ideas of reason and the resulting analogical conception of God that a (...) fully legitimate positive use of the idea of God can be vindicated. (shrink)

Discussions about dispositional and categorical properties have become commonplace in metaphysics. Unfortunately, dispositionality and categoricity are disputed notions: usual characterizations are piecemeal and not widely applicable, thus threatening to make agreements and disagreements on the matter merely verbal—and also making it arduous to map a logical space of positions about dispositional and categorical properties in which all parties can comfortably fit. This paper offers a prescription for this important difficulty, or at least an inkling thereof. This will be achieved by (...) comparing pairs of positions and exploring their background metaphysics to discover where alleged agreements and disagreements concerning dispositionality and categoricity really lie; more specifically, the Pure Powers view and the Powerful Qualities view will be under scrutiny. Over this background, the prescription functions by isolating a successful identity-based characterization of categoricity, while abandoning the correspondent identity-based characterization of dispositionality. On the contrary, according to this prescription a property is dispositional if and only if it is solely in virtue of possessing that property that its bearer is assigned a certain dispositional profile. A crucial consequence of this prescription is that, while supporters of the Pure Powers view often characterize their position as an essentialist one, the dispositionality of properties needn’t always be a matter of essence. (shrink)

We present an elementary system of axioms for the geometry of Minkowski spacetime. It strikes a balance between a simple and streamlined set of axioms and the attempt to give a direct formalization in first-order logic of the standard account of Minkowski spacetime in Maudlin and Malament. It is intended for future use in the formalization of physical theories in Minkowski spacetime. The choice of primitives is in the spirit of Tarski : a predicate of betwenness and a four place (...) predicate to compare the square of the relativistic intervals. Minkowski spacetime is described as a four dimensional ‘vector space’ that can be decomposed everywhere into a spacelike hyperplane—which obeys the Euclidean axioms in Tarski and Givant, 175–214 1999)—and an orthogonal timelike line. The length of other ‘vectors’ are calculated according to Pythagoras’ theorem. We conclude with a Representation Theorem relating models \ of our system \ that satisfy second order continuity to the mathematical structure \, called ‘Minkowski spacetime’ in physics textbooks. (shrink)

The Recursive Bayesian Net formalism was originally developed for modelling nested causal relationships. In this paper we argue that the formalism can also be applied to modelling the hierarchical structure of mechanisms. The resulting network contains quantitative information about probabilities, as well as qualitative information about mechanistic structure and causal relations. Since information about probabilities, mechanisms and causal relations is vital for prediction, explanation and control respectively, an RBN can be applied to all these tasks. We show in particular how (...) a simple two-level RBN can be used to model a mechanism in cancer science. The higher level of our model contains variables at the clinical level, while the lower level maps the structure of the cell's mechanism for apoptosis. (shrink)

In greco antico, i composti che presentino come secondo costituente un sostantivo formato con il suffisso -σις sono molto rari e godono di scarse attestazioni: la maggior parte, infatti, è rappresentata in realtà da derivati da lessemi già composti, soprattutto verbi. Nonostante il significato prototipico dei nomi semplici in -σις sia eventivo, la semantica dei nomi composti in -σις non derivati è perlopiù risultativo-strumentale, per slittamento metonimico; questo fatto è confermato dal comportamento sintattico dei composti in -σις, più vicino a (...) quello dei nomi puri, e quindi generalmente privo di una struttura argomentale. Il secondo costituente di alcuni composti in -σις non è attestato in isolamento, ma l’intero composto è comunque considerabile endocentrico dal punto di vista categoriale. Il suffisso -σις, scarsamente produttivo in composizione, viene sostituito in quest'ambito da suffissi che rientrano nella declinazione tematica, in particolare da -σία, supplendovi invece nella creazione di nomi semplici, in un rapporto analogo a quello che si può evidenziare rispettivamente, nel campo dei nomi d'agente, fra i suffissi -τήρ/-τωρ e -της. (shrink)

This book aims to develop the tradition of philosophical hermeneutics, the theoretical account of interpretive (as opposed to explanatory) understanding--the account of meanings and contexts rather than causes and predictions--usually restricted to the domain of literary and textual analysis, in new directions by exploiting its potential as an instrument of critique. It refutes commonly held claims that hermeneutic analyses are necessarily relativistic, Eurocentric, or critically impotent and demonstrates how hermeneutic procedures can inform analyses of urgent current and cross-cultural issues such (...) as the biology of race, female genital excision, and the so-called "culture of poverty" thesis. Lorenzo Simpson demonstrates that a robust methodology of philosophical hermeneutics is well positioned to intervene in critical political and social issues in global ethics and justice in concert with critical theory's emancipatory aims. (shrink)

The standard representation of the Central Dogma (CD) of Molecular Biology conspicuously ignores metabolism. However, both the metabolites and the biochemical fluxes behind any biological phenomenon are encrypted in the DNA sequence. Metabolism constrains and even changes the information flow when the DNA‐encoded instructions conflict with the homeostasis of the biochemical network. Inspection of adaptive virulence programs and emergence of xenobiotic‐biodegradation pathways in environmental bacteria suggest that their main evolutionary drive is the expansion of their metabolic networks towards new chemical (...) landscapes rather than perpetuation and spreading of their DNA sequences. Faulty enzymatic reactions on suboptimal substrates often produce reactive oxygen species (ROS), a process that fosters DNA diversification and ultimately couples catabolism of the new chemicals to growth. All this calls for a revision of the CD in which metabolism (rather than DNA) has the leading role. (shrink)

It is proper for more reasons than the most obvious one that I should open this talk by quoting a former President of the Royal Institute of Philosophy, Lord Quinton, whose works on political philosophy I have so much enjoyed—and learnt from.

It is proper for more reasons than the most obvious one that I should open this talk by quoting a former President of the Royal Institute of Philosophy, Lord Quinton, whose works on political philosophy I have so much enjoyed—and learnt from.

Karl R. Popper: The open society and its enemies -- Ralf Dahrendorf: Liberty and civil society -- Raymond Plant: Social welfare without class warfare -- Gertrude Himmelfarb and Irving Kristol: The moral imagination -- Raymond Aron: The opium of the intellectuals -- Friedrich A. Hayek: The constitution of liberty -- Isaiah Berlin: Liberty and pluralism -- Michael J. Oakeshott: The conservative disposition -- Leo Strauss: Relativism and the crisis of modernity -- Edmund Burke: Liberty and duty -- James Madison vs. (...) Jean-Jacques Rousseau: Two views of self-government -- Alexis de Tocqueville: Democracy in America -- Winston S. Churchill: The English-Speaking Peoples and the Free World -- Limited and accountable Government -- Two kinds of rationalism -- Liberty as conversation. (shrink)

Cultural evolutionary theory has been alternatively compared to a theory of forces, such as Newtonian mechanics, or the kinetic theory of gases. In this article, I clarify the scope and significance of these metatheoretical characterisations. First, I discuss the kinetic analogy, which has been recently put forward by Tim Lewens. According to it, cultural evolutionary theory is grounded on a bottom-up methodology, which highlights the additive effects of social learning biases on the emergence of large-scale cultural phenomena. Lewens supports this (...) claim by arguing that it is a consequence of cultural evolutionists’ widespread commitment to population thinking. While I concur with Lewens that cultural evolutionists often actually conceive cultural change in aggregative terms, I think that the kinetic framework does not properly account for the explanatory import of population-level descriptions in cultural evolutionary theory. Starting from a criticism of Lewens’ interpretation of population thinking, I argue that the explanatory role of such descriptions is best understood within a dynamical framework—that is, a framework according to which cultural evolutionary theory is a theory of forces. After having spelled out the main features of this alternative interpretation, I elucidate in which respects it helps to outline a more accurate characterisation of the overarching structure of cultural evolutionary theory. (shrink)

A popular stance amongst philosophers is one according to which, in Lewis’ words, “identity is utterly simple and unproblematic”. Building from Lewis’ famous passage on the matter, we reconstruct, and then criticize, an argument to the conclusion that identities cannot be grounded. With the help of relatively uncontroversial assumption concerning identity facts, we show that not all identities are equi-fundamental, and, on the contrary, some appear to be provided potential grounding bases using two-level identity criteria. Further potential grounding bases for (...) identities are presented. Identity might be utterly simple and unproblematic, but this is not sufficient to conclude that identities are ungrounded, or fundamental. (shrink)

In this paper, I offer a systematic account of Kant’s view on ‘phenomenal substance’. Several studies have recently analyzed Kant’s notion of substance. However, I submit that more needs to be said about how this notion is reconceptualized within the critical framework to vindicate a genuine and legitimate sense of substance in the phenomenal realm. More specifically, I show that Kant’s transcendental idealism does not commit him to a rejection of substantiality in phenomena. Rather, Kant isolates a general notion of (...) substance (as ultimate subject) and argues that (i) the relationality of phenomena is compatible with this notion; and that (ii) matter and all its parts are the ultimate subjects of everything existing in space (as what is independently movable in space). I suggest that vindicating a genuine and legitimate notion of phenomenal substance has far-ranging consequences for the interpretation of Kant’s empirical realism. (shrink)

The evolution of the concept of subjectivity in the works of Jacques Lacan.

This article analyses a sceptical challenge resulting from metaphysical approaches to the problem of the necessity of empirical laws of nature in Kant’s critical philosophy (what I shall call ‘essentialist’ readings). I argue that this challenge may jeopardize the purpose of empirical enquiry (and therefore the plausibility of essentialist readings), but that Kant has internal resources to address it in the Dialectic of the Critique of Pure Reason. I show that reading this problem through the lens of the Dialectic allows (...) us to reconcile the metaphysical question of necessitation of laws with a robust sense of empirical cognition. (shrink)

In this paper I would like to reconstruct Patočka’s effort to give a faithful account of the phenomena, without betraying these phenomena with an objectivistic theory of perception. Only by remaining close to the things themselves will we be able to understand them as an appeal, as a call, while understanding ourselves as a response to this call. On the basis of this “ontological rehabilitation of the sensible”, which reveals Patočka’s affinity with Merleau-Ponty as much as his departure from Husserl, (...) I will criticize the idealism of Husserlian phenomenology and reconsider the a priori of correlation in a different fashion. World and subject will then find a different articulation, grounded in the ontological couple of movement and feeling. The analysis will consist of three parts: in the first part I will introduce the problematic of the opposition between phenomenological and physical space; the second part will deal with the notion of movement; the third part will concentrate on Patočka’s new account of subjectivity, the a-subjective cogito, arising precisely from the fundamental coupling of κίνησις and πάθος. Embodiment, qua original phenomenon, will be constantly present in the background of this analysis. (shrink)

This is the first dedicated commentary to Sextus Empiricus’ treatise _Against the Arithmeticians_, dealing with crucial issues in the history of the sceptical, Platonic and Pythagorean traditions and in the ancient philosophy of mathematics.